We report a case of mixed connective tissue disease. A patient, 25-year-old woman, presented Raynaud phenomenon, proximal muscle weakness, sclerodactyly, fever, and diffuse alopecia. In the serologic examination, antinuclear antibody and anti-RNP
antibody were positive but anti-native DNA antibody was negative. In direct immunofluorescent study of biopsy specimen of the skin, speckled epidermal nuclear staining of IgG and granular deposits of IgM at the dermoepidermal junction were seen:
Electromyographic finding of the right deltoid and right gastrocnemius muscle was consistent with myopathy.
(Kor J Dermatol 1992; 30 (6): 932-938)
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